�A year of oral drugs used to treat type 2 diabetes may make heart failure worse, according to an editorial published online in Heart Wednesday by two Wake Forest University School of Medicine faculty members.
"We strongly recommend restrictions in the use of thiazolidinediones (the class of drugs) and question the rationale for leaving rosiglitazone on the market," pen Sonal Singh, M.D., M.P.H., assistant prof of internal medicine, and Curt D. Furberg, M.D., Ph.D., professor of populace health sciences. Rosiglitazone and pioglitazone are the iI major thiazolidinediones.
In the editorial Singh and Furberg say, "At this time, justification for role of thiazolidinediones is identical weak to non-existent."
Oral drugs are granted to control diabetes by lowering origin sugar.
But diabetics also live elevated rates of high blood pressure and high levels of cholesterol and triglyceride, which "further compound their already increased risk of development ischemic ticker disease," Singh and Furberg say. Heart disease and high ancestry pressure "represent conditions that are major precursors of congestive fondness failure."
About 22 percent of diabetics have heart disease. Among aged patients with diabetes, more than half will develop congestive marrow failure
Sunday, 31 August 2008
Thursday, 21 August 2008
Iron Maiden Party Hard On Tour With Paul Gascoigne
Iron Maiden have been celebrating their ongoing European tour with former England footballer Paul Gascoigne, it's been reported.
Gascoigne was patently spotted partying with the band later on a concert in Budapest and was given help walking after one particularly heavy night.
According to the Daily Star, Gascoigne �tried to light up a fag just couldn't get his igniter to his mouth at the same time as his cigarette.�
The footballer had joined Iron Maiden to escape his current minus press in the United Kingdom, the paper claimed.
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Monday, 11 August 2008
Wednesday, 6 August 2008
Scanner
Artist: Scanner
Genre(s):
Soundtrack
Ambient
Metal: Heavy
Electronic
Metal: Power
Soundtrack
Ambient
Metal: Heavy
Electronic
Metal: Power
Discography:
Reason By Heart, Sleep By Twilight
Year: 2005
Tracks: 3
Messe: Macht Ges Klangs/Klang Der Macht
Year: 2005
Tracks: 13
Scantropolis
Year: 2002
Tracks: 10
Lauwarm Instrumentals
Year: 1999
Tracks: 6
Ball Of The Damned
Year: 1997
Tracks: 9
Mental Reservation
Year: 1996
Tracks: 11
Accretions: Mort Aux Vaches
Year: 1996
Tracks: 5
Scanner (Ash 1.1)
Year: 1993
Tracks: 1
Terminal Earth
Year: 1990
Tracks: 10
Hypertrace
Year: 1988
Tracks: 9
Battersea-based ambient composer Robin Rimbaud, aka Scanner, takes his curious nom de guerre from his compositional tool of choice; the cellphone image scanner. Although only recording and cathartic music since the early '90s, Rimbaud has already earned a report as a boundary push experimentalist, wedding ceremony scanned vocal samples with sparse electronics and other textural elements that underline the grade of straining and isolation oft associated with new telecommunications engineering. Though operative more and more toward other, more than than melodic compositional devices, his number 1 several releases went fleshy on the upraised convo, attracting as ofttimes the comment of postgrad pocket theorists interested in the vital implications of Rimbaud's work as the medicinal drug critics. Although admitting to a certain voyeuristical fixation regular in his puerility, Rimbaud's began exploring it through and through medicine only tardy, getting a constabulary digital scanner from the Brixton Hunt and Saboteurs group (a sort of wargames/survivalist collective) at a surprising deduction. He's since recorded a number of albums and completed remixes for Oval, Scorn, and others. Thought non as varied or complex in his coming as some of his peers in the European electronic medicine van, Rimbaud's inquisitory experimentalism and development focus has won him high extolment among the more cerebral of the emusic align, resulting in a move of licenced performance and composition opportunities that develop brought him in tangency with the likes of David Shea, Bill Laswell, Oval's Markus Popp, and Karlheinz Stockhausen (the latter of which Rimbaud counts among his admirers). He likewise worked on the score for the plastic film The Garden Is Full of Metal, around recent film theatre director Derek Jarman. In 2001 Scanner returned with the album Wave of Light by Wave of Light, using the refer Scannerfunk.
Wednesday, 25 June 2008
John Mayer Heading To The Big Screen
John Mayer [ tickets ]'s upcoming DVD release, "Where The Light Is: John Mayer Live in Los Angeles," will be screened in theaters across the US June 30 for one night only. The concert film, recorded last December at LA's Nokia Theater, features Mayer performing an acoustic set, a full-band "Continuum" set and a John Mayer Trio set, according to a press release. "Where The Light Is" will be available in stores July 1 in CD, DVD and Blu-Ray configurations.Mayer, who is scheduled to tour through the end of August, hits the road July 2 in Milwaukee, WI. Various support acts will include Colbie Caillat, Brett Dennen, Paramore and OneRepublic.
Saturday, 21 June 2008
Jesse Sykes and the Sweet Hereafter
Artist: Jesse Sykes and the Sweet Hereafter
Genre(s):
Country
Discography:
Like, Love, Lust and the Open Halls of the Soul
Year: 2007
Tracks: 12
Hollywood studios in a retro mood
For those ready to move past the endless stream of dark dramas from fall 2007, get ready for a new barrage - from the 1960s, the 1940s and the 1780s.
Studios are preparing to unleash a hailstorm of period movies - in broad terms, films set in an era other than the current - in the fall, at times turning the multiplex circa 2008 into a veritable cinematic museum.
The films range from large studio productions - Clint Eastwood's 1920s missing-child drama Changeling and Baz Luhrmann's World War II epic Australia - to specialty releases, like the mid-century Southern tale The Secret Life of Bees and the 1960s Catholic-school drama Doubt.
They veer from costume dramas (the 18th century Keira Knightley quill-and-wig extravaganza The Duchess) to political sagas (Ron Howard's Frost/Nixon) to 1950s family dramas (the Sam Mendes-Leonardo DiCaprio collaboration Revolutionary Road) to biopics (Gus Van Sant's Milk) to yet more WWII throwbacks (Ed Zwick's Defiance, Mikael Hafstrom's Shanghai and Spike Lee's Miracle at St Anna).
"It seems like Hollywood is merging with the History Channel," media critic Robert Thompson noted wryly.
Studios have a long tradition of producing movies set in previous eras, from epics like Ben-Hur to intimate stories like The Ice Storm. But the latest wave of period movies is notable for several reasons.
These movies are coming all at once - scores of pictures crammed into a period of just 10 or 12 weeks.
The stakes and expectations for these movies also are higher because the overall number of fall specialty releases is expected to be down by as much as 25 per cent from the nearly 70 titles released last year.
And, maybe most critical, these period films are being released at a moment when questions linger from last season about whether the audience can find enough to identify with in fall releases.
That combination is enough to make some executives nervous. "It's a lot of period movies, and it's going to be a question of who'll be able to connect," said one high-ranking arthouse-studio executive releasing a period film.
Nonetheless, development executives point to reasons why historical is suddenly fashionable despite the risks.
In a time when summer releases have trumped fall movies on spectacle, they say, it's a chance for films to chisel out a new niche. Boxoffice Mojo president Brandon Gray suggests that period pictures are in effect the fall's answer to the summer tentpole.
"A movie set in period can be a selling point because it transports you to another world without being a fantasy or relying on big special effects," he said.
Period movies can also allow a story to be told in ways that contemporary-set movies can't tell them.
"In a period movie you can strip out modern American irony and ambiguity and get away with it," Thompson said. "A contemporary movie that has absolutes would seems old-fashioned. But if you set it during a previous time, you can make it credible."
Last year, such movies as Michael Clayton, Rendition and In the Valley of Elah took on current issues through a contemporary lens.
This crop looks at equally large themes - the corruption of power (Changeling), the innocent victims of war (Australia, St Anna, Defiance) and the slipperiness of truth (Doubt, Frost/Nixon) - but uses the distancing mechanism of period.
But for all the advantages, will consumers bite on stories that often take place before many of them were born? Executives acknowledge that these movies come with challenges.
"The situations won't be as relatable, so you need to find something relatable that transcends the era," said Fox co-president of theatrical marketing Pam Levine, whose company will try to turn Australia - in which Nicole Kidman and Hugh Jackman cross the Australian outback during a pre-WWII Japanese bombing raid - into a wide play.
Marketing veteran Terry Press, who worked on such period films as Gladiator and Seabiscuit, also sees a fine line. "You don't want to confuse period with old-fashioned (in your marketing). That's the quickest way to lose a big part of the audience."
For a Gladiator spot, DreamWorks cut footage from the film with NFL highlights to give it a modern feel.
Miramax, which undertook a similar promotion for Gangs of New York under the Weinsteins six years ago, will try to bridge the historical and modern in Brideshead Revisited, the class-themed WWII movie based on the Evelyn Waugh novel.
"We want to show people that the issues of class and being an outsider are still very relatable today," Miramax marketing chief Jason Cassidy said.
No matter how the material gets played, though, there might be a commercial ceiling. One development executive points out that "American audiences like occasional period movies, but they do want them every weekend?"
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